Comparative Study of Delayed Cutaneous Hypersensitivity Reactions to the Recall Antigens in Different Dermatoses

Keimyung Medical Journal 1988;7(1):58-63.

수종 피부질환에서 회상 항원에 의한 피부 지연 과민 반응의 비교 연구

김병천; 이규석

Abstract

To assess cell-mediated immunity; We measured delayed cutaneous hypersensitivity by Multi-test® CMI in 108 cases including 20 cases of control; 25 cases of atopic dermatitis; 25 cases of wart; 25 cases of recurrent pyoderma and 13 cases of lymphoma. The results were obtained as follows: 1) Sum of average diameter of positive antigens was 18.86mm in atopic dermatitis; 20.5mm in wart; 25.7mm in pyoderma; 16.15mm in lymphoma and 21.6mm in control. There was no stass tistically significant difference between control and dermatoses. 2) Number of positive antigens was 3.4 in atopic dermatitis; 3.6 in wart; 4.4 in pyoderma; 2.6 in lymphoma and 4.1 in control. There were stastistically significant differences between lymphoma and four other groups(p<0.05). 3) The rate of anergy was 12% in atopic dermatitis and Zero % in four other groups. The rate of hypoergy was 24% in atopic dermatitis and wart; 16% in pyoderma; 62% in lymphoma and Zero % in control. 4) Antigen with highest response was diphtheria (76%) in atopic dermatitis; tuberculin (92%) in wart; diphtheria (80%) in pyoderma; tuberculin (100%) in lymphoma and tuberculin (100%) in control. Antigen with lowest response was trichophyton (8%) in atopic dermatitis; trichophyton (16%) in wart; trichophyton (28%) in pyoderma; diphtheria (15%) in lymphoma and tetanus (10%) in ccntrol. 5) Antigen acquired highest average score was tuberculin (6.1mm) in atopic dermatites; tuberculin (8.1mm) in wart; tuberculin (9.5mm) in pyoderma; diphtheria (9.5mm) in lymphoma and tuberculin (10.2mm) in control. Antigen acquired lowest average score was proteus (3.5mm) in atopic dermatitis; trichophyton (3.4mm) in wart; streptococcus (3.6mm) in pyoderma; tetanus (3.0mm) in lymphoma and tetanus (2.0mm) in control. 6) Average score of total antigens with positive response was 4.8mm in atopic dermatitis; 5.0 mm in wart; 5.7mm in pyoderma; 5.9mm in lymphoma and 4.4mm in control. 7) The rate of false positive reaction to 70% W/V glycerine was 2.8% totally.