| Study of Delayed Cutaneous Hypersensitivity Reactions to the Recall Antigens in Patients with Behcet's Disease |
| 베체트병환자에서 회상항원에 대한 피부 지연과민반응의 연구 |
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김병천; 송준영; 이규석 |
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| Abstract |
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To assess cell-mediated
immunity of patients with Behcet's disease; many studies have been performed by in vitro method. However; there is a little known about cell-mediated immunity of patients with Behcet's disease by in vivo method. Thus; we investigated delayed cutaneous hypersensitivity using Multitest CMI; which is a disposable applicator preloaded with 7 recall antigens; in 82 cases including 62 cases of Behcet's disease and 20 cases of control. Sixty two patients with Behcet's disease were classified into 3 types: complete; incomplete and suspected type according to the revised Shimizu method.
The results were obtained as follows:
1) Sum of average diameter of positive antigens was 6.71土1.10 mm in complete type of Behcet's disease; 12.59±3.48 mm in incomplete type; 7.0±2.0 mm in suspected type; 11.13土3.36 in total of Behcet’s disease and 20.38 士6;06 mm in control. There was stastistically significant difference between Behcet’s disease and contol (p<0. 05).
2) Number of positive antigen was 1.71±0.51 in complete type; 2.29土0.89 in incomplete type; 3.0±1.0 in suspected type; 2.32士0.78 in total of Behcet's disease and 4.01 土1.51 in control. There was stastistically significant difference between Behcet's disease and contol (p<0.05).
3) The rate of hyponergy in Behcet's disease and control was 32.2% and 0%; respectively. The rate of anergy in Behcet's disease and control was 4.8% and 0%y respectively.
4) Antigens acquired strongest reaction were all tuberculin in Behcet's disease(positivity: 81%) and control (95%). Antigens acquired weakest reaction were all tetanus in Behcet's disease (7%) and control (10%). Unexpectedly; the positivity of streptococcus suggested as one of etiologic agents in Behcet's disease was 10% in Behcet’s disease and 56% in control.
Taken altogether; our study revealed cell-mediated immunity of Behcet's disease measured by multitest CM I was decreased and it is suggested that decreased cell-mediated immunity in Behcet's disease is related; at least in part; to the disease severity and involved in the pathogenesis of this disease.
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| Key Words:
Behcet's disease,
Delayed cutaneous hypersensitivity |
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