A Case of Chronic Myeloid Leukemia with Multiple Chloromas Treated Successfully with Dasatinib.

Jang, Won Young; Choi, Sei Myong; Park, Myeong Soon; Ahn, Byung Chan; Heo, Mi Hwa; Kim, Jin Young; Kwon, Ki Young; Do, Young Rok

Case Report

Keimyung Medical Journal 2015;34(2):120-126.
Published online December 15, 2015.

A Case of Chronic Myeloid Leukemia with Multiple Chloromas Treated Successfully with Dasatinib.

Won Young Jang, Sei Myong Choi, Myeong Soon Park, Byung Chan Ahn, Mi Hwa Heo, Jin Young Kim, Ki Young Kwon, Young Rok Do

Divisioin of Hemato Oncology, Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea. dyr1160@dsmc.or.kr

Abstract

Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of the primitive hematopoietic stem cells. CML is characterized by the overproduction of myeloid cells, which results in marked splenomegaly and leukocytosis. CML presented by multiple chloromas is extremely rare. Multiple chloromas in the skin and brain are quite rare as the initial presentation of CML. These rare manifestation should alert clinicians to include CML in the differential diagnosis of patients presenting with multiple non-pruritic skin nodules or neurologic symptoms. Dasatinib has promising therapeutic potential for managing intracranial leukemic disease. Here, we report the case of a patient who visited the hospital with multiple chloroma which is unusual presentation of CML, and treated with dasatinib successfully.

Key Words: Chloroma, Chronic myeloid leukemia, Dasatinib