Clinical Study of Chronic Myelogenous Leukemia

Keimyung Medical Journal 1988;7(1):136-145.

만성골수성 백혈병의 임상적 고찰

여인석; 송홍석

Abstract

A retrospective review is presented for 23 previously untreated patients with chronic myelogenous leukemia between July 1981 through July 1987 at the Keimyung University. The results of study were as follows: The mean age was 38 years with a male to female ratio of 1.1 : 1. On admission; LUQ mass was the most frequent complaint in 12 cases (52.2%) and easy fatigability; general weakness; bleeding; indigestion; weight loss were commonly presented in order of frequency. Physical findings revealed splenomegaly in all cases; hepatomegaly in 10 cases(43.5%); and lymphadenopathy in 2 cases(8.7%). Hematologic findings revealed hematocrit below ll.Ogm/dl in 87% with mean of 9. OCrange: 5.1 ?14.0)gm/dl; leukocyte over 100;000/mm3 in 87% with mean of 241;200(range: 46;500?516;500)/ mm3; and platelet over 800;000/mm3 in 22% with mean of 522;000(range: 170;000?1;112;000)/mm3. Bone marrow aspiration disclosed mean percentage of myeloblast was 3.5% and mean of myeloblast plus promyelocyte was 10.9%. Peripheral leukocytosis was deeply correlated with bone marrow immature cells(p<0.001); but did not relate to spleen size; degree of anemia; peripheral immature cells; and LDH(p<0.01); Cytogenetic study was performed in 10 cases; and there was Philadelphia chromosome in 6 cases; aneuploidy and double minute chromosome in one case; and normal study in 3 cases; and one which performed in blastic phase revealed Ph1; 8 trisomy; and i (17q). Three year survival rate of total 23 cases of busulfan-treated patient is 80% with mean survival time of 42 months; and there was no statistical significance between male and female group Cp<0.1). Key words: Chronic myelogenous leukemia; Cytogenetic study