Abnormal Liver Function Test in Toxemia

Keimyung Medical Journal 1988;7(1):128-135.

임신중독증에서 간기능검사 이상에 관한 연구

강영우; 박승국

Abstract

Toxemia is the first one of three main causes of maternal mortality in Korea; but the pathogenesis is uncertain. Toxemia involves multiple organs and mianifests various clinical symptoms including abnormal liver function test. Although it is transient and disappears after delivery; the clinician always should be aware of it. We analyzed 997 cases of toxemia in 19537 obstetric charts of pregnant women admitted in the department of obstetrics & gynecology; Dongsan Medical Center in a period of ten years from January 1977 to December 1986. The result were as follows: 1) The incidences of abnormal liver profile in toxemia were 5.4% of bilirubin; 82.9% choleste-rrol; 56.6% total protein; 86.4% albumin; 13.9% globulin; 91.9% ALP; 23.2% AST; and 9.4% ALT. 2) Statistical significance between abnormal liver profile and gestational age was observed in total protein; albumin; ALP; and AST(p<0.005). 3) Toxemia compared with abnormal liver profile of nontoxemia group showed statistical significance in all items of liver profile(p<0.005). In conclusion; toxemia result in abnormal liver function test; especially abnormal total protein and AST value in abnormal gestational age.