Xanthine Oxidase Activity in the Regenerating Rat Liver

Keimyung Medical Journal 1987;6(1):95-101.

흰쥐 재생간의 Xanthine Oxidase의 활성치

김여희; 문교철; 곽춘식; 이상일

Abstract

A study was made on the changes in the activities of the following during 10 post-operative days: Serum and hepatic xanthine oxidase (EC 1.2.3.2) alter 70% (median and left lateral lobes) partial hepatectomy in rats. The activities of hepatic total and cytosolic superoxide dismutase (EC 1.15.1.1) and concentration of serum ceruloplamin (EC 1.1G. 3.1) were also measured. After partial hepatectomy in the rats; activity of serum xanthine oxidase tremendously decreased in the span between the second and the third days; however; the activity of this enzyme was markedly elevated from the sixth and the tenth days after operation. And the activity of xanthine oxidase in the regenerating liver significantly decreased from the second days after partial hepatectomy; whereas the activity of this enzyme was markedly elevated from the sixth days after operation. Level of serum ceruloplasmin was markedly increased from the second and the third days after partial hepatectomy in rat. But both hepatic total and cytosolic superoxide dismutase activities were significantly diminished after the second and the third days following partial hepatectomy.