`Comparison of Effect of Uterine Stimulants on Isolated Mouse Uterus

Keimyung Medical Journal 1983;2(1):54-58.

수종 자궁수축제의 마우스의 적출자궁 수축력에 미치는 효과의 비교

이상엽 이만기 주영은

Abstract

The response of the isolated uterus from pregnant (gestational period less than 10 days) and nonprognant mouse to uterine stimulants; oxytocin; prostaglandin (PGF2[7) and ergonovine; was observed in low calcium Tyrode's solution. Potency was represented by the value of pD? which is defined as the negative logarithm of the concentration pnxluctin^ half-maximal response tc> each drug. In the non-pregnant uterus; the pD그 values of oxytocin; PGF2(t; and ergonovine were 8.86’ 6.76’ Lind 6. 7(); respectively. In the pregnant uterus; the values were 8. 45; 7. 50; and 7. 75;respectively. ;V maximal response produced by oxytocin was similar to that by PGF2a in both pregnant and LV)npregnant uterus. However; the maximal response to ergonovine in the nonpregnant uterus was one-twenty fifth the response to oxytocin and PGF2wf and in the pregnant uterus it was a half thu response to them;