Effect of Hypotensive Epidural Anesthesia and Tranexamic Acid
on Perioperative Blood Loss

Keimyung Medical Journal 2012;31(1):56-62.

Effect of Hypotensive Epidural Anesthesia and Tranexamic Acid on Perioperative Blood Loss

저혈압 유도성 경막외 마취와 Tranexamic Acid 투여가 주술기 출혈량에 미치는 효과

이용철; 박지훈

Abstract

We conducted present study to evaluate and compare the effect of hypotensive epidural anesthesia (HEA); tranexamic acid (TA) and combined HEA with TA on reducing perioperative blood loss and transfusion requirements in total hip replacement (THR) under general anesthesia. We reviewed medical records of primary unilateral cementless THR under general anesthesia. Twenty four patients who were underwent HEA were assigned as group 1; twenty three patients who received TA were assigned as group 2; twenty two patients who were underwent HEA and received TA were assigned as group 3. Intraoperative blood loss in group 1; 2; and 3 was 253.5 ± 148.9; 422.4 ± 217.5; and 235.9 ± 119.4 ml; respectively. Group 2 displayed a significantly larger amount of intraoperative blood loss compared to group 1 and 3. Postoperative blood loss in group 1; 2; and 3 was 1074.5 ± 325.5; 477.0 ± 352.7; and 438.7 ± 211.3 ml; respectively. Postoperative blood loss was significantly reduced in group 2 and 3 compared with group 1. Total blood loss in group 1; 2; and 3 was 1326.4 ± 414.2; 913.9 ± 427.5; 675.2 ± 251.4 mL; respectively. Total blood loss was significantly reduced in group 2 and 3 compared with group 1. Combination of HEA and TA administration reduced both intraoperative and postoperative blood loss.

Key Words: Blood loss, Hypotensive epidural anesthesia, Total hip replacement, Tranexamic acid