| pAkt is a Poor Prognostic Factor for Patients with Endometrial Cancer * |
| pAkt 단백 발현이 자궁내막암 예후에 미치는 영향 |
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남동윤; 신소진; 권상훈; 차순도; 조치흠 |
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| Abstract |
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The tumor suppressor PTEN acts as a lipid phosphatase; regulates the
phosphatidylinositol 3-kinase (PI3K)/Akt-signaling pathway; and modulates cell cycle
progression and cell survival. Somatic mutations of PTEN have been reported in a variety of
cancers; especially in endometrial carcinoma. To clarify whether and how the PI3K/Akt pathway
relates to endometrial carcinoma; the expression of those pathway-related proteins in patients
with endometrial carcinoma were examined.
In order to investigate the relationship between phosphorylated Akt (pAkt) expression and
prognosis of endometrial cancer patients; 80 patients with endometrial cancer were enrolled.
Immunohistochemical analysis and western-blot were performed.
Preliminary; western blot analysis from endometrial cancr cell line (Hec-1A and Ishikawa) and
normal endometrial cell lines showed increased expression of pAkt in endometrial cancer cells
compared to normal cells. The mean age was 52.3 years. Stage I were 59 cases; stage II were 5
cases; stage III were 9 cases; stage IV were 2 cases; and unknown stage were 5 cases. Of 80
endometrial carcinomas; 37 cases (46%) showed positive immunohistochemical staining of pAkt.
The survival rate for pAkt negative case was significantly higher than that for pAkt positive cases. These results showed that increased expression level of pAkt was significantly different
according to potential aggressiveness of endometrial cancer (Spearman's correlation coefficient
method p = 0.05). The current study demonstrates that pAkt-positive staining is a significant
indicator of poor survival for patients with endometrial cancer. |
| Key Words:
Endometrial cancer, gene expression, phosphorylated Akt, prognosis |
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