| Analysis of Survival Rate and Prognostic Factors in 3;720 Gastric Cancer Patients
Treated with a Gastric Resection |
| 위절제술을 시행한 위암환자 3;720례의 생존율 및 예후인자 분석 |
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김인호; 손영길; 류승완; 손수상 |
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| Abstract |
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In this retrospective study; 3;720 patients with gastric cancer who underwent
gastric resection at Department of Surgery; Keimyung University Dongsan Medical Center from
January 1990 to December 2006 were reviewed to analyze the clinicopathological characteristics;
survival rate and prognostic factors. The author analyzed 11 clinicopathological variables (sex;
age; tumor location and size; gross and histologic type; Lauren classification; type of operation;
depth of gastric wall invasion; lymph node metastasis; and stage). The male (2;474 patients) to
female (1;246 patients) ratio was 1.99 : 1 and peak age incidence was in the 7th decade with a
mean age of 57.33 ± 11.52 years (range: 19~87 years). The most common location of the tumor
was the lower one third of the stomach (59.0%). Depressed type (84.3%) in early gastric cancer
and Borrmann type III (65.4%) in advanced gastric cancer were the most common gross type.
The major histologic type was poorly differentiated tubular adenocarcinoma (42.0%). In Lauren
classification; the incidence of diffuse type (46.7%) and that of intestinal type (46.3%) were
similar. The incidence of early gastric cancer was 45.8%. The operations performed were subtotal
gastrectomy in 3;115 patients (83.7%) and total gastrectomy in 598 patients (16.1%). The
postoperative mortality rate was 0.8%. The overall 5-year survival rate was 70.5%. The
univariate analysis for prognosis reveals that increasing age; tumor location in upper one third; larger tumor size; Borrmann’s type Ⅲ and Ⅳ tumors; poorly differentiated histologic type; diffuse
type in Lauren classification; total gastretomy; increasing pT and pN classification; and advanced
tumor stage were significantly related to poor prognosis. The multivariate analysis revealed that
lymph node metastasis; depth of invasion; age and Borrmann's classification were independent
prognostic factors. |
| Key Words:
Gastric cancer, gastrectomy, survival rate, prognostic factors. |
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