Role of Ischemic Modified Albumin as Early Sensitive Marker of
Transient Myocardial Ischemia

Keimyung Medical Journal 2006;25(2):167-173.

Role of Ischemic Modified Albumin as Early Sensitive Marker of Transient Myocardial Ischemia

일과성 심근 허혈에 민감한 조기 표지자로서 Ischemic Modified Albumin의 역활

김민정; 김권배; 전동환; 조현옥; 박창욱; 김형섭; 남창욱; 한성욱; 허승호; 김윤년; 이영수; 김기식

Abstract

Human albumin undergoes a significant reduction in its capacity to bind exogenous cobalt soon after transient coronary occlusion by percutaneous transluminal coronary angioplasty (PTCA). We investigated the changes of ischemic modified albumin(IMA) level following transient myocardial ischemia. We enrolled forty patients who diagnosed as chronic stable angina. These patients divided into 2 groups. Twenty seven patients who underwent PTCA were as group 1; 13 patients who underwent diagnostic coronary angiography as group 2. Venous samples were obtained 15 minutes; 1 hour; 6 hours and 12 hours after procedures. In group 1; the level of IMA was 97.7±15.4 U/mL at basal and 116.6±13.1 U/mL at 15 minutes; which was significantly increased than basal. In group 2; The IMA level was significantly increased from basal (96.0±6.8 U/mL) to 15 minutes (104.3±6.6 U/mL). The difference IMA levels was statistically significant (p<0.001) in both groups until 1 hour. The changes of the IMA can be an early sensitive marker of transient myocardial ischemia and may have a role in very early ischemic event.

Key Words: Albumin, Myocardial ischemia, Percutaneous transluminal coronary angioplasty