| Morphologic and
Cytologic Changes of Brain in OLETF Diabetic Rat:
Comparision of MRI Finding with Gross Specimen and Evaluation of Cerebral
Blood-Brain Barrier by EM |
| OLETF 당요쥐 뇌의 형태 및 세포학적 변화: 자기공명영상과 육안적 조직검사와의 비교 및 전자현미경을 이용한 뇌 혈뇌장벽의 고찰 |
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권재수; 손철호; 우성구; 서수지; 김상표; 이인규 |
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| Abstract |
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Diabetes me lb't us (DM)
chronically afflicts the central nervous system (CNS) in several ways; and increases stroke risk and damage; and the prevalence of seizure disorders. Physiologically. DM changes ion transport system; blood flow and metabolism of the brain; and may produce a chronic encephalopathy. Consequently; cerebrovascular accidents; such as lacunar infarction and hemorrhage; commonly occur in diabetic patients. Using magnetic resonance imaging and light microscopy; we studied gross cerebral lesions in fiveOtsuka Long Evans Tokushima Fatty COLEFT) rats and two control Long-Evans Tokushima Otsuka (LETO) rats and evaluated tlx1 blood-brain barrier in OLBTF and LETO rats using electron microscopy; lioth OLETF and LETO rats did not reveal any gross abnormalities in both MRI and light microscopic images. Only OLETF rats had blood-brain barrier abnormality; including thickening of basement membrane and increased micro-organelles of cytoplasm of endothelial cells under a transmission electron microscope. The finding of basement membrane thickening of endothelial cells seems to be common in both OLETF and stropiofcotocin induced diabetic rat. The finding of increased micro-organdies of cytoplasm of endothelial cells is tin.1 unique pathologic finding that has not previously been reported. The results in the present study suggest that the endothelial cdl of blood-train barrier is a target of diabetic microangiopathy. |
| Key Words:
Blood-brain barrier,
Diabetes mellitus, Experimental study, Magnetic resonance image |
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