| Experimental Model
of Pneumonia Induced by
Pneumocystis carinii |
| 폐포자층 폐렴의 실험적 모델 |
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정혜라; 김희경; 신용억; 심지훈; 권건영 |
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| Abstract |
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Pneumocystis carinii (P. carinii) is
an opportunistic pathogen which
causes pneumonia in the lungs of immunocompromised patients. Since the
organism has not been successfully propagated in vitro; many investigators have
been restricted to in vivo models for studing the P. carinii organisms. This study
was carried out to investigate more desirable animal model of P . carinii
pneumonia and to observe morphologic characteristics in the animal model of rats.
After six weeks of administration of 8% low protein diet; dexamethasone;
tetracycline; and nystatin; the Sprague-Dawley rats were sacrificed to submit
lungs and bronchoalveolar lavage for the study. We compared between the oral
administration and intraperitoneal injection of dexamethasone to the experimental
rats. The oral administration of dexamethasone was more effective than the
intraperitoneal injection of dexamethasone for the survival rates and detection
rates of P. carinii in the rats. The survival rates and detection rates of P. carinii
were similar between the group of intratracheal injection of P. carinii plus oral
dexamethasone administration and the group of only oral dexamethasone
administration. These results indicated that the oral administration of
dexamethasone in the experimental rats is more convenient and effective method
to make a desirable P. carinii animal model and to observe morphologic
characteristics of P. carinii pneumonia in rats. |
| Key Words:
Animal model,
Morphologic characteristics, Pneumocystis carinii |
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