A Case of Reversible
Adriamycin-Induced Cardiomyopathy |
Adriamycin에 의해 유발된 가역적인 심근병증 1례 |
장용석; 조주연; 허지안; 도영록; 송홍석 |
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Abstract |
Adriamycin is a
chemotherapeutic agent highly effective against a
wide range of neoplasms. A primary limiting factor to the administration of this
drug is a cardiotoxicity; which frequently develops when the cumulative dose
exceeds 500 mg/m3. Cardiomyopa isolated from the common bile duct (CBD)
ligated rats; which were injected with taurocholic acid (TCA); The activities of
liver cytosolic; mitochondrial and microsomal PAT as well as their Vmax values
were found to be significantly increased in the CBD ligation plus TCA injected
group than in the control group; such as CBD ligation alone group. However; their
Km values in the experimental group did not vary. On the other hand; these hepatic
enzyme activities did not change in the CBD ligation plus tauroursodeoxycholic
acid injected group. Therefore; the above results indicate that TCA stimulates
biosynthesis of the PAT in the livery and echocardiography. |
Key Words:
Adriamycin,
Cardiomyopathy |