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Keimyung Medical Journal 1999;18(3):418-427.
Effects of Isolated Cerebral Perfusion with Cold Saline on Extracellular Hippocampal Glutamate and Glycine Concentrations in Rabbits
냉각식염수로 분리뇌관류가 토끼 해면구 세포 외액의 Glutamate; Glycine 농도에 미치는 영향
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Abstract
Background. When ischemia reduces blood qua non for reducing demand. An alternative isolated cerebral hypothermia via perfusion supply; hypothermia remains the sine whole body deep hypothermia is an cooled blood through one internal carotid artery. The goal of this study was to evaluate the effect of isolated cold hemisphere perfusion during the cerebral ischemia on pernschemic glutamate and glycine concentrations
Methods
Experiments were carried out with animal (New Zealand White rabbit) Rabbit was to perfuse a saline solution into carotid artery with a cold salme(20°C). Animals were devided into two groups In experimental group; the cerebral ischemia was produced by a combination of carotid artery saline perfusion and systemic hypotension to a mean arterial blood pressure of 40 mmHg for 10 minutes and control group received no perfusion during the ischemia.
Results
. Glutamate and glycine concentrartions during ischemia m the experimental group showed increased significantly compared to control group(p < 0 05)
Conclusions
. Cerebral cold saline perfusion during the ischemia did not prevent increase of glutamate and glycine during ischemia. These results showed hypothemia induced by selective brain perfusion may not be one of the most effective ways to protect brain from the ischemia
Key Words: Glutamate, Glycine, Isolated Cerebral Perfusion, Hypothermia
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