| Effect of Common
Bile Duct Ligation on Glyoxalase II Activity in Ethanol Intoxicated Rat Liver
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| 주정 중독 흰쥐 간의 Glyoxalase Ⅱ 활성에 미치는 총담관 결찰의 영향 |
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노태연; 김여희 |
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| Abstract |
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To understand the
biochemical background of alcohol hazards in hepatobiliary disease; the activities of the rat liver cytosolic and mitochondrial glyoxalase- II (GLO- II) were measured in cholestasis induced by common bile duct (CBD) ligation after chronic ethanol intoxication; and in cholestasis before acute ethanol intoxication.
GLO-II activities in the rat's liver cytosol and mitochondria showed more decrease when CBD was ligated after chronic ethanol intoxication than that in the CBD ligation alone.
On the other hand; when CBD was ligated after chronic ethanol intoxication; the value of Vmax of the liver cytosolic and mitochondrial GLO-II decreased significantly than that in the CBD was ligated alone. However; the values of Km of the liver cytosolic and mitochondrial GLO- Q did not change in the all experimental groups.
Viewed from above results; when chronic ethanol intoxication is combined with cholestasis; GLO-n in the liver seems to be decreased its activity than that in cholestasis; and the cause of the decrease is thought to be decreased biosynthesis. Accordingly; this result will be the datum supporting that alcoholic drink to be enzymologically harmful in hepatobiliary disease.
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| Key Words:
Ethanol intoxication,
Cholestasis, Glyoxalase II |
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