A Case of Doxorubicin Induced Cardiomyopathy

Keimyung Medical Journal 1990;9(2):269-275.

Doxorubicin에 의한 심근증 1례

권치한; 황종문; 권태찬; 강진무

Abstract

Doxorubicin is effective chemotherapeutic agent in the treatment of various solid tumor and hematologic malignancies Because of its cardiotoxicity; however; early inappropriate discontinuation of doxorubicin therapy is unavoidable and may minimize its therapeutic efficacy in may patients Doxorubicin cardiotoxicity is dose related and the cardiomyopathy is fatal in over half the cases Authers have experienced a case of doxorubicin induced cardiomyopathy in a 4 years old girl who diagnosed as having Wilms tumor right side and treated with vincristine; actmomycin; and doxorubicin (total cumulative dose is 345mg/M2) She also had right nephrectomy and irradiation to the right kidne> area Brief review of the literature was made

Key Words: Doxorubicin, Cardiomyopathy