| Glutathione S-Transferase; Glutathione Reductase and Glutathione Peroxidase Activities in Cholestatic Rat Liver
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| 흰쥐 담즙울체간의 Glutathione S-Transferase; Glutathione Reductase 및 Glutathione Peroxidase의 활성도 |
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권용철; 문교철; 곽춘식 |
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| Abstract |
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Changes in the activities of the following enzymes have been studied over a period of forty two days after the ligation of common bile duct in rats cytosolic; mitochondrial and microsomal glutathione S-transferase; cytosolic glutathione reductase and cytosolic glutathione peroxidase of cholestatic liver
The activity of cytosolic glutathione S-transferase in the cholestatic rat liver strikingly diminished between the third and the forty-second days after the ligation of common bile duct and that of mitochondrial glutathione S-transferase also showed significant decrease between the fourteenth and the forty-second days after operation However; the microsomal glutathione S-transferase activity in the cholestatic rat liver showed a substantial increase between the seventh and twenty-eight days after operation
The cytosolic glutathione reductase activity in the cholstatic rat liver elevated considerably between the second and the forty-second days after operation; but the cytosolic glutathione peroxidase activity in the cholestatic rat liver had a significant diminution between the fourteenth and the forty-second days after the ligation of common bile duct
Key Words Cholestatic liver; Glutathione S-Transferase;Glutathione Reductase; Glutathione peroxidase
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