| Prognostic Significance of Hypermethylation and
Expression of p16, p21, and p53 Genes in Diffuse Large
B-cell Lymphoma |
| Prognostic Significance of Hypermethylation and
Expression of p16, p21, and p52 Genes in Diffuse Large
B-cell Lymphoma |
|
Hye Ra Jung; Sun Young Kwon; Mi Sun Choe; Yu Na Kang; Sang Pyo Kim; Kun Young Kwon; Sang Sook Lee |
|
|
|
|
| Abstract |
|
Diffuse large B-cell lymphoma (DLBCL) accounts for approximately 30?40% of
non-Hodgkin's lymphomas. Significant molecular prognostic markers of DLBCL are not well
known. In this study; hypermethylation of p16; p21 and p53 gene and protein expression of p16;
p21; and p53 in DLBCL were investigated with 91 paraffin blocks. Hypermethylation of p16 gene
was more common than hypermethylation of p21 or p53 in DLBCL. Hypermethylation of p21 gene
was highly related to recurrence and reduced expression of p21 protein showed a strong
tendency of poor survival. For an individual patient with DLBCL; if the tumor shows
hypermethylation of p21 gene; it may make to predict the increased risk of recurrence. If the
tumor shows reduced p16 expression; and/or methylation of p53 gene; it is important to consider
that this markers are related to higher international prognostic index; which help to predict
outcome of patients. |
| Key Words:
Large B-cell, Lymphoma, methylation, prognosis, p16, p21, p53 |
|
PDF Links
Full text via DOI
Download Citation
